分类: 物理学 >> 普通物理:统计和量子力学,量子信息等 提交时间: 2017-11-02 合作期刊: 《热科学学报》
摘要: Most evaporative cooling towers are arranged on building roof due to the limitation of space and noise, and acoustic barriers are always installed around cooling towers in practical applications. The existence of acoustic bathers and crosswind may affect the recirculation phenomenon which is directly related to the operating performance of cooling towers. In this study, a physical and mathematical computation model is proposed to research the crosswind and distance between acoustic bathers and inlet of cooling towers. Both sensible and latent heat are considered in this research. The reflux flow rate and performance ratio are obtained to evaluate the recirculation and operating performance, respectively. The results show that the higher the crosswind velocity, the larger the reflux flow rate, and the lower the performance ratio of cooling tower groups. For high crosswind velocity, the presence of acoustic barriers is useful to inhibit reflux and improve operating performance, especially for ICE cooling tower groups. In addition, the optimum values are recommended for LiBr/ICE cooling tower groups in the research cases The variation of reflux flow rate and performance ratio with the acoustic bathers' distance presents a parabolic tendency.
分类: 地球科学 >> 空间物理学 提交时间: 2017-03-31
摘要: Ulysses magnetic and plasma data are used to study hourly-scale Alfv{\'e}nic fluctuations in the solar polar wind. The calculated energy ratio $R^2_{v_A}$(cal) of inward to outward Alfv{\'e}n waves is obtained from the observed Wal{\'e}n slope through an analytical expression, and the observed $R^2_{v_A}$(obs) is based on a direct decomposition of original Alfv{\'e}nic fluctuations into outward- and inward-propagating Alfv{\'e}n waves. The radial variation of $R^2_{v_A}$(cal) shows a monotonically increasing trend with heliocentric distance $r$, implying the increasing local generation or contribution of inward Alfv{\'e}n waves. The contribution is also shown by the radial increase in the occurrence of dominant inward fluctuations. We further pointed out a higher occurrence ($\sim 83\%$ of a day in average) of dominant outward Alfv{\'e}nic fluctuations in the solar wind than previously estimated. Since $R^2_{v_A}$(cal) is more accurate than $R^2_{v_A}$(obs) in the measurement of the energy ratio for dominant outward fluctuations, the values of $R^2_{v_A}$(cal) in our results are likely more realistic in the solar wind than previously estimated and than $R^2_{v_A}$(obs) in our results. The duration ratio $R_T$ of dominant inward to all Alfv{\'e}nic fluctuations increases monotonically with $r$, and is about two or more times that from {\it Voyager 2} observations at $r \geq 4$~AU. Finally, from the variation trend in our results, a higher (lower) occurrence rate is expected at $r 4$~AU) for dominant outward Alfv{\'e}nic fluctuations, and opposite variations are expected for dominant inward fluctuations. Simultaneously, $R^2_{v_A}$(cal) and $R_T$ will be expected to be smaller at $r 4$~AU. These results reveal new qualitative and quantitative features of Alfv{\'e}nic fluctuations therein compared with previous studies and put constraints on modelling the variation of solar wind fluctuations.
分类: 生物学 >> 生态学 提交时间: 2017-11-17
摘要: A novel dipeptidyl peptidase IV inhibitor hit (5, IC50 = 0.86 mu M) was structurally derived from our recently disclosed preclinical candidate 4 by replacing the cyanobenzyl with a butynyl based on pharmacophore hybridization. A hit-to-lead optimization effort was then initiated to improve its potency. Most N-substituted analogs exhibited good in vitro activity, and compound 180 (IC50 = 1.55 nM) was identified to be a potent dipeptidyl peptidase IV inhibitor with a significantly improved pharmacokinetic properties (bioavailablity: 41% vs 82.9%; T-1/2: 2 h vs 4.9 h). (C) 2013 Elsevier Ltd. All rights reserved.
分类: 生物学 >> 生态学 提交时间: 2017-11-17
摘要: We previously reported a highly potent DPP-IV inhibitor 6 with low in vivo efficacy. While trying to maintain consistent in vitro and in vivo biological activity, we initiated a pharmacokinetic property-driven optimization to improve the metabolic stability and permeability of inhibitor 6. A simple scaffold replacement of thienopyrimidine with pyrrolopyrimidine (21a) led to significantly improved metabolic stability (4% vs. 65% remaining). Further modification of the pyrrolopyrimidine scaffold to produce compound 21j resulted in much better oral bioavailability than 6. Importantly, compound 21j exhibits greater in vivo efficacy than does 6 and Alogliptin and is worthy of further development. (C) 2012 Elsevier Masson SAS. All rights reserved.